Community signal

@Nick2k25 Oh yeah. So you can get 50/10/10/10 KLOW and add 20mg more each of BPC-157, TB4 and 5mg more of KPV and transf

@Nick2k25 Oh yeah. So you can get 50/10/10/10 KLOW and add 20mg more each of BPC-157, TB4 and 5mg more of KPV and transfer it to a bigger vial. The standard issue ChiCom KLOW is decent, but I’m really big into bigger doses of the BPC-157 and TB4 (and a bit bigger KPV) these days for max effectiveness

Mentions BPC-157

@Nick2k25 I've heard a lot of similar stories like this. Really glad to hear this. Did you use oral or injected KPV?

@Nick2k25 I've heard a lot of similar stories like this. Really glad to hear this. Did you use oral or injected KPV?

Mentions KPV

What other people say about BPC-157: https://t.co/7QGuUroPsn

What other people say about BPC-157: https://t.co/7QGuUroPsn

Mentions BPC-157

the BPC-157 I take — Barrier Health, enteric-coated tablets, 500mcg. the coating is the whole thing. plain capsules get

the BPC-157 I take — Barrier Health, enteric-coated tablets, 500mcg. the coating is the whole thing. plain capsules get destroyed by stomach acid, which is why most people feel nothing after six weeks and write it off. ALFRED = 15% off https://t.co/bbQQkcxcjy

Mentions BPC-157

BPC-157 healed almost every injury they tested it on. ➤ tendon cut off bone — reattached in 21 days ➤ nerve sliced in h

BPC-157 healed almost every injury they tested it on. ➤ tendon cut off bone — reattached in 21 days
➤ nerve sliced in half — reconnected
➤ spinal cord crushed — walking again
➤ hole through an eye — sealed in 24h
➤ bone sawed out — matched a graft
➤ muscle torn off bone — reattached
➤ gut perforated by ibuprofen — closed every one of these are built to be permanent. every control group stayed broken. injury that's been there for years? one you've stopped mentioning? I take the oral version every morning. everything's in the replies ↓

Mentions BPC-157

“Signaling molecules shouldn’t be macro dosed” sounds good until you look at the actual MOTS-c literature. AMPK activat

“Signaling molecules shouldn’t be macro dosed” sounds good until you look at the actual MOTS-c literature. AMPK activation isn’t the only endpoint. Researchers have reported dose-dependent effects on endurance, glucose metabolism, mitochondrial adaptation, and cellular stress responses. Nobody is claiming 5x the dose gives 5x the AMPK signal. The question is whether greater exposure produces greater downstream biological effects. For MOTS-c, the evidence suggests it often does.

Mentions MOTS-c

Or buy your MOTS-c from https://t.co/dzeRFW4NqQ that already comes in a 6ml vial. And we have a guarantee. If your vial

Or buy your MOTS-c from https://t.co/dzeRFW4NqQ that already comes in a 6ml vial. And we have a guarantee. If your vial gels or doesn’t perform like you want it, we will replace it for free. Every time. We also do include sterile empty 10ml vials with another 30mg product. WELCOME15 for 15% off your first order.

Mentions MOTS-c

my bicep tendon had refused to heal for months on BPC-157 ... took normal standard subq dose, guess i should of added tb

my bicep tendon had refused to heal for months on BPC-157 ... took normal standard subq dose, guess i should of added tb500? feels dissapointing? where that magic at

Mentions BPC-157

Learn how to optimize for strength, vitality, and longevity inside my Living Leaner. Longer. Stronger. Masterclass. htt

Learn how to optimize for strength, vitality, and longevity inside my Living Leaner. Longer. Stronger. Masterclass.  https://t.co/0fNHTEDgCu https://t.co/QquYcaYAU6

what I noticed on oral BPC-157. the bloating went first, inside a week. I hadn't realised how normal that tight feeling

what I noticed on oral BPC-157. the bloating went first, inside a week. I hadn't realised how normal that tight feeling after eating had become until it wasn't there. the head cleared after that. less of the fog I'd been blaming on sleep. the back took eight weeks. twelve years of nerve damage, two doctors, both said permanent. one person, no control group, and I wanted it to work. I know what that does to what you notice. but that's the order it happened in.

Mentions BPC-157

same peptide, other tissues: ➤ tendon cut off bone — reattached in 21 days ➤ spinal cord crushed — recovered ➤ nerve se

same peptide, other tissues: ➤ tendon cut off bone — reattached in 21 days
➤ spinal cord crushed — recovered
➤ nerve severed — reconnected
➤ hole through an eye — sealed in 24h
➤ bone sawed out — matched a graft thirty years. no dose has ever killed anything. https://t.co/87tj9RDwVP

it's BPC-157. a 15-amino-acid fragment of something already in your gastric juice. the oral version I take — Barrier He

it's BPC-157. a 15-amino-acid fragment of something already in your gastric juice. the oral version I take — Barrier Health, enteric-coated tablets, 500mcg. plain capsules get destroyed by stomach acid, which is why most people feel nothing and write it off. ALFRED = 15% off https://t.co/5HSNWbgD8V

Mentions BPC-157

I used to roll my eyes when people suddenly lost loads of weight and credited keto or “just eating less.” I suspected GL

I used to roll my eyes when people suddenly lost loads of weight and credited keto or “just eating less.” I suspected GLP-1s and thought they should admit it. Then I started Zepbound. Promised myself I’d be open about it. A year later, thirty pounds down, almost nobody knows. When people ask, I lie.

Mentions Tirzepatide

@Max_hubz KPV

@Max_hubz KPV

Mentions KPV

I avoided SSRIs because the side effects scared me. Always wanted to do things https://t.co/hRRXLj8MSk I inject Selank..

I avoided SSRIs because the side effects scared me. Always wanted to do things https://t.co/hRRXLj8MSk I inject Selank... honestly? I feel better!! Social anxiety had reached the point where even being around longtime friends felt uncomfortable. On Selank, conversations became easier and I stopped analysing myself so much.

Mentions Selank

@SSavson https://t.co/rNNujLF2qy https://t.co/GsNR9f3gbg https://t.co/Gey0XkHBRq https://t.co/dv927j0sim This is going

@SSavson https://t.co/rNNujLF2qy https://t.co/GsNR9f3gbg https://t.co/Gey0XkHBRq https://t.co/dv927j0sim This is going to be big. You can see all the investors salivating over it. And just like GLP1 drugs, I already solved this problem. 🤣

@AtomP2P I don’t think so. The copper is bound to the GHK.

@AtomP2P I don’t think so. The copper is bound to the GHK.

You’re searching for a GLP-1 but don’t know what the costs are for each of the pharmacies if you have to have a membersh

You’re searching for a GLP-1 but don’t know what the costs are for each of the pharmacies if you have to have a membership, etc. Check this out ⬇️ https://t.co/6w1UmwEjhQ

Living Leaner Longer Stronger is my blueprint for optimal health and longevity... Built from 25+ years of research, exp

Living Leaner Longer Stronger is my blueprint for optimal health and longevity... Built from 25+ years of research, experimentation, and real-world application. Get your copy on Amazon or read 2 chapters! https://t.co/XhdmGdW0gC https://t.co/cC3Im7vk03

I love being tan year-round on Melanotan II. What bothers me is how quickly I get used to the colour and start wanting

I love being tan year-round on Melanotan II. What bothers me is how quickly I get used to the colour and start wanting to be darker again.

circadion = epitalon btw https://t.co/IMer5CJIbQ

circadion = epitalon btw https://t.co/IMer5CJIbQ

Mentions Epitalon

bryan once did 5 days of epitalon and never mentioned it again. i wonder why. https://t.co/8VICsGo5RN

bryan once did 5 days of epitalon and never mentioned it again. i wonder why. https://t.co/8VICsGo5RN

Mentions Epitalon

Do you have an injury that never came back right? BPC-157 HEALED every version of that they could build in a lab. ➤ sp

Do you have an injury that never came back right? BPC-157 HEALED every version of that they could build in a lab. 
➤ spinal cord crushed — recovered
➤ nerve severed — reconnected
➤ hole through an eye — sealed in 24h
➤ bone sawed out — matched a graft
➤ muscle torn off bone — reattached every one built to be permanent. every control group stayed broken. (PMID: 16583442 · 31266512 · 10071911) the one you train around. the one you've stopped mentioning. the one they told you to live with. everything's in the replies ↓

Mentions BPC-157

@GilaMonstrum @JCanNuSH @ObsvRetardation It's very weird to compare tiny Phase 1 data versus large phase 3 trials. Cagri

@GilaMonstrum @JCanNuSH @ObsvRetardation It's very weird to compare tiny Phase 1 data versus large phase 3 trials. Cagrisema phase 3 diabetes had serious AE events from ~8-13% if we're doing that. Otherwise this study did what it was supposed to. That's the whole point of phase 1. Ph2 diabetes has one outlier

Mentions CagriSema

GHK-Cu isn’t as flashy as some of the other peptides but it’s actually a real banger. https://t.co/7n4xBP4CPi

GHK-Cu isn’t as flashy as some of the other peptides but it’s actually a real banger. https://t.co/7n4xBP4CPi

Mentions GHK-Cu

Chinese pharma grade Cerebrolysin (allegedly)? Came in a box with instructions. Let’s see how it goes. Starting day 2

Chinese pharma grade Cerebrolysin (allegedly)? Came in a box with instructions. Let’s see how it goes. Starting day 2 of 10 now. https://t.co/Jo75RBC82w

Mentions Cerebrolysin

@NovaForgeLab @RegenRandy Since starting TRT, I haven't gotten a single pimple. Not sure if KPV helped, but no acne. It

@NovaForgeLab @RegenRandy Since starting TRT, I haven't gotten a single pimple. Not sure if KPV helped, but no acne. It also seemed to help 9th Life, so worth a shot!

Mentions KPV

@HDeezeez For KPV or KLOW? The only limiting factor with KLOW is the GHKcu. The standard dosage for GHKcu is 2.5mg. Fo

@HDeezeez For KPV or KLOW? The only limiting factor with KLOW is the GHKcu. The standard dosage for GHKcu is 2.5mg. For KPV, really it’s up to you but 500mcg or 1mg is good. You can do every day, every other day, or 5 days on 2 days off. I personally prefer daily and .5mg to 1mg.

Mentions KPV

My non peptide transformation : Subject: Metabolic Reset: The One-Month Bloodwork and Progress Report I want to share

My non peptide transformation : Subject: Metabolic Reset: The One-Month Bloodwork and Progress Report I want to share a complete update on the health protocol I’ve been running up here at the camp in New Sweden. A little over a month ago, I tipped the scale at 108.5 kilos (roughly 239 pounds). Today, I am holding between 207 and 209 pounds. My size 38 pants are loose, and I am on the glide path back to the 34-inch waist I had as a younger man. I forced this physical shift by locking into a militant 18:6 daily fasting schedule and overhauling my diet. I stripped out the heavy, saturated fats and shifted to a massive, high-protein plant-based protocol—relying on extra-firm tofu, beans, non-fat Greek yogurt, and walnuts to fuel my 6-foot-6 frame. The weight loss is highly visible, but the real victory is what just happened inside my body. I got my comprehensive bloodwork back today, and the results are a massive cause for celebration. In just over a month, I have completely rebuilt my metabolic engine. Here is the biological proof: * The Kidneys and Boundless Energy: My kidneys are operating with the absolute flawless efficiency of a much younger man. With a GFR of 96.7 and a Creatinine of 0.86, they are under zero strain. This internal repair has translated into a massive surge in systemic energy; my body feels revitalized, lighter, and clear-headed in a way I haven't experienced in years. * The Liver (Fatty Liver Reversed): My AST dropped to 23 and my ALT is 21. Both are in the optimal healthy range. The visceral fat that was suffocating my liver is gone, and the inflammation has completely stopped. My liver is now a highly optimized, fat-burning machine. * The Heart (Arteries Clearing): Last year in Lebanon, my LDL cholesterol was in the danger zone at 174. By eliminating saturated dairy and oils, I have driven my LDL down an astonishing 60 points to 114, entirely without pharmaceutical statins. I am actively clearing the plaque out of my arteries. * Blood Sugar (Prediabetes Defeated): Last year, my fasting glucose was creeping into the warning zone at 102. Today, my non-fasting glucose was a perfect 99. My insulin sensitivity is completely repaired; my body is instantly soaking up fuel instead of leaving it trapped in my blood. The only friction I’ve experienced recently was a bout of severe leg cramps, which the blood test perfectly diagnosed. Because the 18-hour fast is aggressively burning through my glycogen stores, my kidneys are flushing out massive amounts of water and taking my salt with it (my sodium dropped to 128). I’m actively fixing this now by heavily salting my food, eating feta cheese, and taking dedicated zero-carb electrolytes. I am healthier now than I have been in years, with the biological markers to prove it. I’ve already taken my typhoid vaccine, and this physical baseline means my body is fully armored and ready for the upcoming travels through Mexico and South America. Give my love to everyone 💕 – Todd

what I noticed on oral BPC-157. the bloating went first, inside a week. I hadn't realised how normal that tight feeling

what I noticed on oral BPC-157. the bloating went first, inside a week. I hadn't realised how normal that tight feeling after eating had become until it wasn't there. the head cleared after that. less of the fog I'd been blaming on sleep. the back took eight weeks. twelve years of nerve damage, two doctors, both said permanent. one person, no control group, and I wanted it to work. I know what that does to what you notice. but that's the order it happened in.

Mentions BPC-157

it's animals. the only controlled human data on this peptide is 16 people with chronic knee pain — retrospective, no con

it's animals. the only controlled human data on this peptide is 16 people with chronic knee pain — retrospective, no control group. I say this every time. https://t.co/C7bclWVMGJ

what other people say about BPC-157: unedited. the pattern is nearly always the same — nothing for ten to fourteen days

what other people say about BPC-157: unedited. the pattern is nearly always the same — nothing for ten to fourteen days, then it starts. these are anecdotes. so is mine. posting them as what they are. https://t.co/rl6KoHFifm

Mentions BPC-157

same peptide, other tissues: ➤ tendon cut off bone — reattached in 21 days ➤ spinal cord crushed — recovered ➤ nerve se

same peptide, other tissues: ➤ tendon cut off bone — reattached in 21 days
➤ spinal cord crushed — recovered
➤ nerve severed — reconnected
➤ hole through an eye — sealed in 24h
➤ bone sawed out — matched a graft thirty years. no dose has ever killed anything. https://t.co/SoIFdaXXu2

the source: https://t.co/BIYs0BWYqR the image above is Figure 1 — the burn model. deep partial-thickness burns covering

the source: https://t.co/BIYs0BWYqR the image above is Figure 1 — the burn model. deep partial-thickness burns covering 20% of total body area, open flame, 5 to 7 seconds. left is untreated. right is BPC-157 one week in. Figure 2 in the same paper has the diabetic wounds and the ligated-artery wounds.

Mentions BPC-157

it's BPC-157. a 15-amino-acid fragment of something already in your gastric juice. the oral version I take — Barrier He

it's BPC-157. a 15-amino-acid fragment of something already in your gastric juice. the oral version I take — Barrier Health, enteric-coated tablets, 500mcg. plain capsules get destroyed by stomach acid, which is why most people feel nothing and write it off. ALFRED = 15% off https://t.co/5HSNWbgD8V

Mentions BPC-157

I'm planning on using the following stack. Reta, Mots-c, Ipamorelin, Tesamorelin. Has anyone used a stack like this befo

I'm planning on using the following stack. Reta, Mots-c, Ipamorelin, Tesamorelin. Has anyone used a stack like this before and what are your results? Also what (REDACTED) would you recommend?

Mentions Tesamorelin

@checkcasherKBD different people see different effects from it depending on where your baseline is pinealon morning is

@checkcasherKBD different people see different effects from it depending on where your baseline is pinealon morning is best for most people, epitalon evening. if pinealon feels sedating then evening better.

Mentions Epitalon

"why increase DHT its only good for penile growth and beard growth" is what you say when you havent read the research.

"why increase DHT its only good for penile growth and beard growth" is what you say when you havent read the research. - increases bone thickness - neuroprotective - increases sex drive and sexual function - enhances IGF-1 signaling - boosts height growth - shrinks gyno i am not saying you dont have any of the listed things without DHT. i am simply saying DHT has these effects, as shown in studies. DHT has its benefits, DHT has its downsides. to claim it only has downsides and should be nuked or only has benefits and should be injected is false.

@HughHoyland literally just people who dont understand the nuance behind it. They apply it to HGF and thus dihexa but f

@HughHoyland literally just people who dont understand the nuance behind it. They apply it to HGF and thus dihexa but forget to also apply it to every other neurotrophic factor. Ill explain their logic with an example: BDNF is linked to cancer. Exercise increases BDNF. So exercise causes cancer. No. See how stupid this sounds?

Mentions Dihexa

"dihexa causes cancer" more like "dihexa causes me to remember more and learn faster" HGF overexpression, which is whe

"dihexa causes cancer" more like "dihexa causes me to remember more and learn faster" HGF overexpression, which is where dihexa acts, enhances learning and memory. https://t.co/6iUxpC6Xp6

Mentions Dihexa

@Johnfromtravajo KLOW is a blend of KPV, BPC-157, TB-500, and GHK-Cu. The ratios are usually 500mcg / 500mcg / 500mcg /

@Johnfromtravajo KLOW is a blend of KPV, BPC-157, TB-500, and GHK-Cu. The ratios are usually 500mcg / 500mcg / 500mcg / 2.5mg per dose. So if you’re already taking all four, it’s pretty convenient

Mentions BPC-157

Based AF. Stop focusing on the headline of maximum % weight loss in clinical trials. Retatrutide is not automatically b

Based AF. Stop focusing on the headline of maximum % weight loss in clinical trials. Retatrutide is not automatically better than Tirzepatide just because morbidly obese people lose slightly more weight, at higher dosages but higher side effects. What maintains muscle will win.

Mentions Retatrutide

Learn how to optimize for strength, vitality, and longevity inside my Living Leaner. Longer. Stronger. Masterclass. ht

Learn how to optimize for strength, vitality, and longevity inside my Living Leaner. Longer. Stronger. Masterclass.  https://t.co/0fNHTEDgCu https://t.co/jmzdj5iR3B

I swapped put a reta label on a pt141 vial and gave it to a friend

I swapped put a reta label on a pt141 vial and gave it to a friend

I agree with you here. Though we get our blends right, the timing is the issue you can’t control with a blend. I’m curre

I agree with you here. Though we get our blends right, the timing is the issue you can’t control with a blend. I’m currently running AHK-Cu in place of GHK-Cu for 8 weeks. Why? Not entirely sure. Grey hair caused by GHK-Cu maybe? The copper degradation is a Reddit cesspool myth though. Since it’s bound to the GHK, it’s not roaming around causing trouble.

Mentions GHK-Cu

ALFRED = 25% off. worth saying plainly — every human trial used IV infusion in a hospital. nobody has shown a subcutane

ALFRED = 25% off. worth saying plainly — every human trial used IV infusion in a hospital. nobody has shown a subcutaneous shot at home reproduces it. it's a research peptide. not approved for anything. https://t.co/DaeJI2AjBj

KPV is the quiet S-tier peptide that should be part of everyone’s daily stack. Most of you are inflamed and don’t even

KPV is the quiet S-tier peptide that should be part of everyone’s daily stack. Most of you are inflamed and don’t even know it. Puffy face, skin that stays red, gut that never feels right. That is not “just stress.” Chronic inflammation is how a lot of disease starts. Cancer included. KPV lowers inflammation throughout the body. It helps with: - face puffiness - acne - rosacea / eczema - psoriasis - gut issues - histamine flares That’s it. If you haven’t tried it, it’s one you really should.

Mentions KPV

For those asking, I get my KPV from Peptide Supply Co You can stack it with code PEPTIDES for extra 10% savings https:

For those asking, I get my KPV from Peptide Supply Co You can stack it with code PEPTIDES for extra 10% savings https://t.co/vMQWqNcTug https://t.co/WiVQ6mvtSg

Mentions KPV

When I started peptides about 6 years ago now, this was long before ChatGPT and vibe coding. of the resources out there

When I started peptides about 6 years ago now, this was long before ChatGPT and vibe coding. of the resources out there existed today. I’ll never forget the first time I reconstituted and pinned that BPC-157, just waiting for something awful to happen. It didn’t. Magic happened instead.

Mentions BPC-157

@longevitymediaa Not with Reta. We haven’t seen the specific muscle loss numbers for Reta, but I suspect it would be su

@longevitymediaa Not with Reta. We haven’t seen the specific muscle loss numbers for Reta, but I suspect it would be substantially less than both Semaglutide (30% of weight loss is muscle) and Tirzepatide (20%) My guess is it’s probably between 5 and 10%

Mentions Semaglutide

Eli Lilly is launching LillyDirect to deliver Mounjaro straight to Australian patients’ doors — and local doctors and ph

Eli Lilly is launching LillyDirect to deliver Mounjaro straight to Australian patients’ doors — and local doctors and pharmacists aren’t thrilled. https://t.co/vzdOTI5s2h

Mentions Tirzepatide

@DadBodWorx Tesamorelin S-Tier

@DadBodWorx Tesamorelin S-Tier

Mentions Tesamorelin

Average peptide vendor "express shipping, premium"

Average peptide vendor "express shipping, premium"

In Australia, Eli Lilly is launching LillyDirect to deliver Mounjaro straight to patients’ doors. Patients still need a

In Australia, Eli Lilly is launching LillyDirect to deliver Mounjaro straight to patients’ doors. Patients still need a prescription, but there’s concern the model strips away face-to-face oversight for a powerful class of drugs. https://t.co/wSV07UiGwH

Mentions Tirzepatide

Longevity product marketing is out of control, but there are established FDA pathways for the evidence required to get a

Longevity product marketing is out of control, but there are established FDA pathways for the evidence required to get approvals. A @ScienceMagazine policy forum "Rather than leaning into deregulation, dedicating resources to validating endpoints and to enforcing existing regulation is what will best serve the public, advance science, and promote innovation." https://t.co/A5ztBcMAM8

@Compound_Cowboi You’re spot on. Ozempic Face Prevention is GHK-Cu.

@Compound_Cowboi You’re spot on. Ozempic Face Prevention is GHK-Cu.

Mentions Semaglutide

If you’re looking for a top notch research peptide vendor, head on over to https://t.co/TID6Jts0Qj for a great combinati

If you’re looking for a top notch research peptide vendor, head on over to https://t.co/TID6Jts0Qj for a great combination of product quality, customer service, shipping speed and checkout ease. WELCOME15 gets you 15% off your first order.

Body still recovering from the mosh pit. mind is telling me to stay in bed where it’s nice and warm. i can’t tell y’all

Body still recovering from the mosh pit. mind is telling me to stay in bed where it’s nice and warm. i can’t tell y’all to stay locked in and then i stay in bed like a fraud. straight to the fkn gym. •3iu gH •1mg mots-c •2mg. Slu-pp-332 •200mg modafanil •10mg tadalafil 🔒 it’s going to be a great day today

Mentions MOTS-c

it's a research peptide. not approved for anything, anywhere. I'm not taking it and I'm not recommending it. I'm postin

it's a research peptide. not approved for anything, anywhere. I'm not taking it and I'm not recommending it. I'm posting it because the human data is unusually good for this space and almost nobody has seen it.

the JAMA trial is the one I'd read. these men had normal testosterone. their hormones weren't the problem. and kisspept

the JAMA trial is the one I'd read. these men had normal testosterone. their hormones weren't the problem. and kisspeptin still changed what their brains did while watching sexual material, and still increased physical arousal. that means it's doing something centrally, not just through hormones.

Mentions Kisspeptin

the limits, and they're real: every human study used IV infusion in a clinical setting. continuous, measured, monitored

the limits, and they're real: every human study used IV infusion in a clinical setting. continuous, measured, monitored. nobody has shown that a subcutaneous shot at home reproduces any of it. and twice-daily dosing of the longer form lost its effect by day 14. the receptor stops responding.

why "above everything TRT targets" matters: TRT gives you the end product. your brain detects it, stops sending the sig

why "above everything TRT targets" matters: TRT gives you the end product. your brain detects it, stops sending the signal, and your own production shuts down. that's why testicles shrink and fertility drops. kisspeptin works at the top of the chain. it tells your system to produce, rather than replacing what it makes. opposite direction entirely.

Mentions Kisspeptin

testosterone INCREASED 44% in men who took this peptide. kisspeptin-10. it works one level above everything TRT targets

testosterone INCREASED 44% in men who took this peptide. kisspeptin-10. it works one level above everything TRT targets. your hypothalamus releases it, it tells the pituitary to release LH, LH tells the testes to make testosterone. it's the signal that starts the chain. IV infusion for 22.5 hours in healthy men: LH from 5.4 to 20.8. testosterone from 16.6 to 24.0 nmol/L. (PMID: 21632807) TRT shuts that system down. this turns it up. then 2023, JAMA. 32 men with low desire and normal testosterone. randomised, placebo-controlled, fMRI. it changed activity in the sexual brain network and increased arousal — in men whose hormones were already fine. the limits: every study was an IV infusion in a hospital. nobody has shown a shot at home does the same. more in the replies ↓

Mentions Kisspeptin

"is it the same as BPC-157?" no. different origin, different mechanism. BPC-157 is a fragment of a gastric protein and

"is it the same as BPC-157?" no. different origin, different mechanism. BPC-157 is a fragment of a gastric protein and works mainly through tissue repair and new blood vessel growth. KPV is a fragment of a hormone and works by shutting down inflammatory signalling. one rebuilds, one calms down.

Mentions BPC-157

no human trials. I want to be blunt about that because the peptide sellers aren't. cells and mice. that's it. eighteen

no human trials. I want to be blunt about that because the peptide sellers aren't. cells and mice. that's it. eighteen years since the paper and nobody has run a proper trial in people.

PepT1 is normally a nutrient transporter — it moves small peptides from digested protein across the gut wall. in a heal

PepT1 is normally a nutrient transporter — it moves small peptides from digested protein across the gut wall. in a healthy colon it's barely expressed. in inflamed tissue it goes up. that's why the absorption improves with damage. the transporter is responding to the inflammation, and KPV happens to fit through it.

Mentions KPV

the hormone it comes from is alpha-MSH — the one involved in pigmentation, appetite and immune signalling. KPV is the l

the hormone it comes from is alpha-MSH — the one involved in pigmentation, appetite and immune signalling. KPV is the last three amino acids of it. the anti-inflammatory activity survived the cut. the pigment and appetite effects didn't.

Mentions KPV

the study: https://t.co/rpascDF9K5 Dalmasso et al., Gastroenterology 2008. free full text at https://t.co/Sl6inus1OT h

the study: https://t.co/rpascDF9K5 Dalmasso et al., Gastroenterology 2008. free full text at https://t.co/Sl6inus1OT human cell lines first, then two separate mouse colitis models. KPV delivered orally in drinking water.

Mentions KPV

KPV gets absorbed better the SICKER your gut is. what is it? three amino acids — lysine, proline, valine. the tail end

KPV gets absorbed better the SICKER your gut is. what is it? three amino acids — lysine, proline, valine. the tail end of a hormone your body ALREADY makes. what does it do? it rides in on a transporter called PepT1, which only ramps up in INFLAMED TISSUE. the more damage, the more gets in. inside, it shuts down NF-κB and MAPK — the two switches driving inflammatory bowel disease. at nanomolar concentrations. almost nothing. they dissolved it in drinking water and gave it to mice with colitis. two separate models. inflammation dropped in both. (PMID: 18061177) no human trials. none. cells and mice, that's the whole evidence base. eighteen years since that paper. nobody has run the human version. more in the replies ↓

Mentions KPV

if elon musk switched out ketamine for 5-MeO-DMT adderall for desoxyn or vyvanse benzo's for daridorexant add some cere

if elon musk switched out ketamine for 5-MeO-DMT adderall for desoxyn or vyvanse benzo's for daridorexant add some cerebrolysin he would be on mars already https://t.co/8cnByHgygA

Mentions Cerebrolysin

@NovaForgeLab It’s one I use daily. Keep in my stack ever since starting it. Only briefly did I stop to test if it was t

@NovaForgeLab It’s one I use daily. Keep in my stack ever since starting it. Only briefly did I stop to test if it was the KPV or something else, sure enough, it was the KPV helping

Mentions KPV

@incomingracks @subqsundays Peptide Supply Co You can use their pack builder to save more and stacks with 10% with code

@incomingracks @subqsundays Peptide Supply Co You can use their pack builder to save more and stacks with 10% with code PEPTIDES https://t.co/6x0nrRLskR

@ManOnThePen @JCanNuSH Yes it is. Oral macrocyclic peptide.

@ManOnThePen @JCanNuSH Yes it is. Oral macrocyclic peptide.

not necessarily it increases REM, and if you're only sleeping 6h, that extra REM has to come from somewhere, it changes

not necessarily it increases REM, and if you're only sleeping 6h, that extra REM has to come from somewhere, it changes the distribution of the sleep you're already getting. thing is most people aren't sleeping deep enough to properly get a large amount of deep sleep or rem in the first place. which pinealon helps with. it also restores your sleep architecture and deepness of sleep in general. agreed on pinealon morning and epitalon before bed. this is how i am running it too.

Mentions Epitalon

@PepRoundUp @MrDudesDad But seriously. 95%+ of what's in a typical peptide vial isn't the peptide. Elemental weight does

@PepRoundUp @MrDudesDad But seriously. 95%+ of what's in a typical peptide vial isn't the peptide. Elemental weight doesn't matter here. So to say "the APIs come from China it's all the same" is really saying "OK so 5% of this vial comes from China but the other 95%, is mystery powder I have absolutely no idea what Eva from WhatsApp put in there and she won't tell me."

@MrDudesDad @PepRoundUp Take a look at one of your vials of Chinese peps. When you have a 10mg peptide vial, what percen

@MrDudesDad @PepRoundUp Take a look at one of your vials of Chinese peps. When you have a 10mg peptide vial, what percent of the powder in that vial would you say is that 10mg? That big cake you’re so used to seeing. Keep in mind 10mg is just a pinch. For reference, a teaspoon of sugar is 4,000mg.

@Boshnackttack1 @4WhomJBellTolls Lol. I have one of the top stem cell clinics in the United States. I’m also one of the

@Boshnackttack1 @4WhomJBellTolls Lol. I have one of the top stem cell clinics in the United States. I’m also one of the top prescribing Peptide physicians, and I’m bored certified in family Medicine and sports Medicine, and run a very complex practice in Miami.

Found a great deal on 100mg of GHK-Cu, so decided to go full Rory and get a pen to hold all that blue zombie milk. One d

Found a great deal on 100mg of GHK-Cu, so decided to go full Rory and get a pen to hold all that blue zombie milk. One day, staring in the mirror, I decided to squirt 4mg on my balding head. Why not? We're researchers, no?

Mentions GHK-Cu

FDA officials sketch how a therapy targeting aging might reach approval, revealing longevity is an FDA priority Yeah, t

FDA officials sketch how a therapy targeting aging might reach approval, revealing longevity is an FDA priority Yeah, that’s a big deal https://t.co/VRnCAHnRKH

Myostatin is one of the most fascinating biological brakes on muscle growth. And human genetics give us a glimpse into

Myostatin is one of the most fascinating biological brakes on muscle growth. And human genetics give us a glimpse into what happens when that brake is naturally turned DOWN. People with certain heterozygous loss-of-function variants affecting myostatin may produce less functional myostatin and some reported cases show greater muscularity and lower body fat. Then you have the EXTREMELY rare cases where both copies of the gene are disrupted. The result? Dramatically reduced myostatin signaling and extraordinary muscular development from a very young age. This is WHY myostatin has become such an interesting target in the world of muscle preservation, sarcopenia, and longevity research. Because maintaining MUSCLE as we age isn't just about aesthetics. Muscle is metabolic currency. And understanding the biological signals that regulate it could completely change how we approach healthy aging. Guys and Gals… We are only beginning to understand how powerful these pathways really are.

The list of GLP-1 drug benefits independent of weight loss keep growing https://t.co/ptW5KGMHem

The list of GLP-1 drug benefits independent of weight loss keep growing https://t.co/ptW5KGMHem

@SeroBass1 This in turn fuels healthy liver and improves keytone production and other things that liver need to maintain

@SeroBass1 This in turn fuels healthy liver and improves keytone production and other things that liver need to maintain metabolic health. Basically, you run hotter. When you supplement TRT, you don't have this other effect going on so the body can't compensate by running hotter.

@SeroBass1 Some people on TRT are infertile for 24 months or more. You burn out your balls because they can't respond ap

@SeroBass1 Some people on TRT are infertile for 24 months or more. You burn out your balls because they can't respond appropriately to thermal demands. Good luck.

@SeroBass1 So with some weird irony, if you're taking testosterone replacement therapy, you might actually want to use t

@SeroBass1 So with some weird irony, if you're taking testosterone replacement therapy, you might actually want to use this to prevent your testicles from getting damaged. Low fertility is a common consequence of TRT.

@zachbuilds Pepfanatics is a satire ai peptide page, says so in their bio

@zachbuilds Pepfanatics is a satire ai peptide page, says so in their bio

Is Eli Lilly getting sloppy? Its retatrutide crackdown caught an unrelated transportation company, which had to supply d

Is Eli Lilly getting sloppy? Its retatrutide crackdown caught an unrelated transportation company, which had to supply documentation explaining that it had nothing to do with Astra Peptides. Lilly dropped the company from the lawsuit; its case against the peptide seller remained. Same name. Rather different line of work. Full article below.

Mentions Retatrutide

GLP-1s for longevity? https://t.co/VGU9b971uQ

GLP-1s for longevity? https://t.co/VGU9b971uQ

Regeneron's experimental antibody helped patients who stopped Wegovy regain about as much muscle as they had lost on the

Regeneron's experimental antibody helped patients who stopped Wegovy regain about as much muscle as they had lost on the drug. https://t.co/mYu1wqAXqd

Mentions Semaglutide

Saudi Arabia Joins the War on Grey-Market Peptides Saudi Arabia is taking legal action against online sellers of unregi

Saudi Arabia Joins the War on Grey-Market Peptides Saudi Arabia is taking legal action against online sellers of unregistered peptides, with potential penalties of five years in prison and SAR 5 million in fines. An earlier investigation traced retatrutide supplies from gym trainers to a warehouse. The latest announcement names no sellers or compounds, but adds another enforcement action to the growing pressure on the grey market. link to my full article below

Mentions Retatrutide

@WillGLP1 What did your glucose curve look like before starting GLP-1? Has the medication changed your fasting glucose

@WillGLP1 What did your glucose curve look like before starting GLP-1? Has the medication changed your fasting glucose, post-meal spike, or how long it takes to return to baseline?

The peptide industry still needs a lot more policing. I just came across a “company” using what appear to be completely

The peptide industry still needs a lot more policing. I just came across a “company” using what appear to be completely fabricated COAs. For starters, I can’t even verify that the lab named on them exists. Best case, the customer gets 0 peptide. Worst case, they get some random compound or even roids. We recently saw a peptide company get indicted after allegedly selling steroids as peptides.

6/ The waterfall plots: 41% of placebo patients GAINED weight. On retatrutide, only 2–3% failed to lose weight. On 12 mg

6/ The waterfall plots: 41% of placebo patients GAINED weight. On retatrutide, only 2–3% failed to lose weight. On 12 mg, individual results ranged from +7% to −55%. The mean hides some extreme responders. https://t.co/lbIuL377OK

Mentions Retatrutide

2/ Mechanism: GLP-1 + GIP + glucagon. Glucagon raises glucose, so why add it? The incretin arms offset that effect, and

2/ Mechanism: GLP-1 + GIP + glucagon. Glucagon raises glucose, so why add it? The incretin arms offset that effect, and what remains is hepatic fat oxidation and higher energy expenditure. Patients eat less and burn more. https://t.co/oiNhoGizAc

1/ The phase 3 retatrutide data is out (TRIUMPH-1, 2,339 pts, 80 wks). The headline is 28.3% weight loss on 12 mg. But t

1/ The phase 3 retatrutide data is out (TRIUMPH-1, 2,339 pts, 80 wks). The headline is 28.3% weight loss on 12 mg. But the headline is the least interesting part of the paper. A clinician's read 🧵 https://t.co/PWB7gd8GwK

Mentions Retatrutide

@iamandrewz Turn peptide confessions, into vendor trapfession

@iamandrewz Turn peptide confessions, into vendor trapfession

@TAGS_LABEL_CO Nice to see a peptide business that does not sell peptides

@TAGS_LABEL_CO Nice to see a peptide business that does not sell peptides

Peptide research gets weird. This Friday, @troywhiteyyc sits down with Juan (@TwoCarbonsApart) to hear the strangest r

Peptide research gets weird. This Friday, @troywhiteyyc sits down with Juan (@TwoCarbonsApart) to hear the strangest research he’s come across. 4 PM MT, live on @pepfessions. Bring your questions. https://t.co/l6HKNftmBD

@7_investor If you have to use 2 “doses” of a “lethal injection” drug (which I’m assuming is Pentothal) then, by definit

@7_investor If you have to use 2 “doses” of a “lethal injection” drug (which I’m assuming is Pentothal) then, by definition, it’s not “lethal.”

@ChasteJDVance It’s hard to speak to the pharma guidelines whether they’re empirical, practical or just arbitrary. Testo

@ChasteJDVance It’s hard to speak to the pharma guidelines whether they’re empirical, practical or just arbitrary. Testosterone cypionate for instance, they say it only lasts I think 28 days. It’s why many prescriptions come in 1ml vials instead of 10ml. But we all now it’ll last much longer. Bacteriostatic water and the 28 day rule is another that’s been disproven empirically. There are empirical tesamorelin degradation tests out there. I’ll DM you one.

Mentions Tesamorelin