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Associations between high perceived stress, inflammatory proteins, and BDNF: a cross-sectional study of young adult females in Shanghai, China.

Mentions Oxytocin

Hunger pain and its reduction; qualitative insight from people with schizophrenia on semaglutide.

1. Int J Qual Stud Health Well-being. 2026 Dec 31;21(1):2717809. doi: 10.1080/17482631.2026.2717809. Epub 2026 Aug 18. Hunger pain and its reduction; qualitative insight from people with schizophrenia on semaglutide. Rasmussen BS(1), Simonÿ C(1)(2)(3), Poulsen ML(1), Uhrenholt NG(1)(4), Lundberg B(1)(5), Rønne ST(6), Uhrenholt PG(1)(7), Gæde PH(1)(3)(8), Arnfred SM(1)(7). Author information: (1)Department of Research, Central and Western Zealand Hospital, Copenhagen University Hospital, Slagelse, Denmark. (2)The Research and Implementation Unit PROgrez, Central and West Zealand Hospital, Slagelse, Denmark. (3)Institute of the Regional Health, University of Southern Denmark, Odense, Denmark. (4)Department of Clinical Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark. (5)Central and Western Zealand Hospital, Psychiatry South, Vordingborg, Denmark. (6)Department of Research & Psychiatry Westh, Central and Western Zealand Hospital, Copenhagen University Hospital, Slagelse, Denmark. (7)Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. (8)Department of Internal Medicine, Central and Western Zealand Hospital, Geriatrics and Neurology, Slagelse, Denmark. PURPOSE: It is often reported that people with schizophrenia experience weight gain and disordered eating, partly due to antipsychotics. As part of the RCT "Home-based Intervention with Semaglutide Treatment of Neuroleptic-Related Prediabetes, HISTORI", the present study investigates experiences of hunger and eating habits in people using antipsychotics during semaglutide treatment. METHODS: Eleven semi-structured interviews were conducted 4 months to 1,5 years after treatment completion. Six women and 5 men were interviewed. The interviews were analysed using Braun & Clarke's reflexive thematic analysis. RESULTS: Three themes were identified; "Hunger pain induced by antipsychotic medicine", "Positive and negative experiences of reduced hunger", and "Eating habits and what influences them". The term "Hunger pain" was applied. It defines an excruciating combination of feeling extremely hungry, never achieving satiety, and relentless preoccupation with thoughts about food. The analysis suggested a focus on the patients' coping styles. CONCLUSION: The hunger pain, probably induced by antipsychotics, seemed to reinforce maladaptive coping styles. The relief from hunger pain due to semaglutide was in most cases a liberation. Yet, it is important also to pay attention to the negative effects of reduced hunger. It is relevant to assess patients' eating problems prior to semaglutide treatment. DOI: 10.1080/17482631.2026.2717809 PMCID: PMC13487855 PMID: 42610532 [Indexed for MEDLINE] Conflict of interest statement: The HISTORI RCT: Financial, material, and other support for the study was obtained from private foundations, including the Novo Nordisk Foundation; the Steno Diabetes Centre Sjaelland; the Steno Diabetes Centre Odense, Denmark; Slagelse Research Grants; and Region Zealand Health Research Foundation. The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Mentions Semaglutide

Rethinking dog stress behaviours: contextual and physiological insights from the attachment framework.

Mentions Oxytocin

Limosilactobacillus reuteri normalizes gut microbiota dysfunction and social deficits of rat offspring associated with prenatal exposure to stress.

Mentions Oxytocin

Exploring spin-phonon coupling, barocaloric, and polar phonon features in the multiferroic [(CH(3))(2)NH(2)][Mn(N(3))(3)] hybrid perovskite.

Mentions P21

ATR-FTIR spectroscopy coupled with multivariate analysis for monitoring degradation and secondary structure transitions in therapeutic peptide formulations.

Mentions Semaglutide

Associations between human oxytocin receptor gene promoter DNA methylation and brain structural connectome in panic disorder in Korea.

1. J Affect Disord. 2026 Dec 15;415:122425. doi: 10.1016/j.jad.2026.122425. Epub 2026 Aug 26. Associations between human oxytocin receptor gene promoter DNA methylation and brain structural connectome in panic disorder in Korea. Kim HJ(1), Pae C(2), Bang M(1), Kim IB(3), Lee SH(4). Author information: (1)Department of Psychiatry, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea. (2)Brain Imaging Center, Seoul National University, Seoul, Republic of Korea. (3)Department of Psychiatry, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Republic of Korea. Electronic address: ilbin49@chamc.co.kr. (4)Department of Psychiatry, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea. Electronic address: drshlee@cha.ac.kr. AIMS: Epigenetic regulation of the oxytocin receptor gene (OXTR), particularly DNA methylation (DNAm), has been linked to insecure attachment, anxiety-related phenotypes, and suicidality. However, its role in panic disorder (PD) and brain network dysfunction remains unclear. This study examined whether peripheral OXTR DNAm and OXTR DNAm-associated structural connectivity are related to clinical symptoms of PD. METHODS: We investigated OXTR DNAm and its structural connectivity in 563 patients with PD and 210 healthy controls (HCs). Peripheral blood OXTR promoter (-934) DNAm was quantified by pyrosequencing. In a neuroimaging subset, diffusion MRI tractography reconstructed the structural connectome. Network-based statistics tested the diagnosis-by-OXTR DNAm and diagnosis-by-clinical symptomatology effects using separation-related life events (SLEs), Anxiety Sensitivity Index-Revised (ASI-R), and the Scale for Suicidal Ideation (SSI). A preliminary bagging ensemble regression model was used to evaluate treatment response prediction. RESULTS: Patients with PD exhibited significantly lower OXTR DNAm levels than HCs, adjusting for age, sex, education, smoking status, and body mass index. Within PD, reduced OXTR DNAm was significantly negatively correlated with elevated SLEs, ASI-R, and SSI scores. Diagnosis-by-OXTR DNAm interactions revealed reduced connectivity across the hippocampus, amygdala, orbitofrontal, and precentral regions converging on the extended fear network. Importantly, OXTR DNAm-associated connectivity in the orbitofrontal and lateral occipital cortices showed a cross-validated association with the 8-week treatment outcomes. CONCLUSION: Lower peripheral OXTR DNAm was associated with higher PD-related symptomatology and altered extended fear network connectivity. These findings suggest that peripheral OXTR DNAm may index aspects of clinical and neural heterogeneity in PD. Copyright © 2026 Elsevier B.V. All rights reserved. DOI: 10.1016/j.jad.2026.122425 PMID: 42648552 [Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Mentions Oxytocin

Discovery of a novel and potent KRAS(G12V)-targeting peptide with antiproliferative activity against colorectal cancer cells.

1. J Enzyme Inhib Med Chem. 2026 Dec;41(1):2684700. doi: 10.1080/14756366.2026.2684700. Epub 2026 Jun 11. Discovery of a novel and potent KRAS(G12V)-targeting peptide with antiproliferative activity against colorectal cancer cells. Zhang H(1), Yang S(2), Wang Y(2), Niu MM(2), She J(3). Author information: (1)Department of Hepatobiliary Surgery, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China. (2)Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, Jiangsu, China. (3)Department of Gastrointestinal Surgery, Jintan Affiliated Hospital of Jiangsu University, Changzhou, Jiangsu, China. Despite the clinical relevance of KRASG12V in colorectal cancer, KRASG12V-specific inhibitors remain limited. Through structure-based virtual screening of a 59,319-member peptide library, we identified four KRASG12V-targeting peptides, among which Peptide-1 showed the most favourable docking profile. MST assays confirmed Peptide-1 had the highest affinity among Peptides 1-4, with stronger binding to KRASG12V than to other KRAS mutants. Structural analysis, molecular dynamics simulations, and free-energy calculations indicated that Peptide-1 formed a stable and energetically favourable complex with KRASG12V through extensive hydrogen bonding and hydrophobic interactions. Peptide-1 showed favourable human serum stability and cellular NanoBRET-supported engagement with KRASG12V. Functionally, Peptide-1 displayed potent antiproliferative activity in colorectal cancer cell lines, weaker effects on normal cells and reduced efficacy after KRASG12V knockdown. In SW480 cells, Peptide-1 was associated with reduced ERK1/2 phosphorylation, p21 upregulation, and G0/G1 accumulation. Overall, these findings support further investigation of Peptide-1 as a KRASG12V-targeting peptide for colorectal cancer drug discovery. DOI: 10.1080/14756366.2026.2684700 PMCID: PMC13262105 PMID: 42274165 [Indexed for MEDLINE] Conflict of interest statement: No potential conflict of interest was reported by the authors.

Mentions P21