What the peptide community is saying — and living

Associations between high perceived stress, inflammatory proteins, and BDNF: a cross-sectional study of young adult females in Shanghai, China.

is it really necessary to inject ghk-cu at night?

is it really necessary to inject ghk-cu at night?

I used to roll my eyes when people suddenly lost loads of weight and credited keto or “just eating less.” I suspected GL

I used to roll my eyes when people suddenly lost loads of weight and credited keto or “just eating less.” I suspected GLP-1s and thought they should admit it. Then I started Zepbound. Promised myself I’d be open about it. A year later, thirty pounds down, almost nobody knows. When people ask, I lie.

Hunger pain and its reduction; qualitative insight from people with schizophrenia on semaglutide.

1. Int J Qual Stud Health Well-being. 2026 Dec 31;21(1):2717809. doi: 10.1080/17482631.2026.2717809. Epub 2026 Aug 18. Hunger pain and its reduction; qualitative insight from people with schizophrenia on semaglutide. Rasmussen BS(1), Simonÿ C(1)(2)(3), Poulsen ML(1), Uhrenholt NG(1)(4), Lundberg B(1)(5), Rønne ST(6), Uhrenholt PG(1)(7), Gæde PH(1)(3)(8), Arnfred SM(1)(7). Author information: (1)Department of Research, Central and Western Zealand Hospital, Copenhagen University Hospital, Slagelse, Denmark. (2)The Research and Implementation Unit PROgrez, Central and West Zealand Hospital, Slagelse, Denmark. (3)Institute of the Regional Health, University of Southern Denmark, Odense, Denmark. (4)Department of Clinical Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark. (5)Central and Western Zealand Hospital, Psychiatry South, Vordingborg, Denmark. (6)Department of Research & Psychiatry Westh, Central and Western Zealand Hospital, Copenhagen University Hospital, Slagelse, Denmark. (7)Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. (8)Department of Internal Medicine, Central and Western Zealand Hospital, Geriatrics and Neurology, Slagelse, Denmark. PURPOSE: It is often reported that people with schizophrenia experience weight gain and disordered eating, partly due to antipsychotics. As part of the RCT "Home-based Intervention with Semaglutide Treatment of Neuroleptic-Related Prediabetes, HISTORI", the present study investigates experiences of hunger and eating habits in people using antipsychotics during semaglutide treatment. METHODS: Eleven semi-structured interviews were conducted 4 months to 1,5 years after treatment completion. Six women and 5 men were interviewed. The interviews were analysed using Braun & Clarke's reflexive thematic analysis. RESULTS: Three themes were identified; "Hunger pain induced by antipsychotic medicine", "Positive and negative experiences of reduced hunger", and "Eating habits and what influences them". The term "Hunger pain" was applied. It defines an excruciating combination of feeling extremely hungry, never achieving satiety, and relentless preoccupation with thoughts about food. The analysis suggested a focus on the patients' coping styles. CONCLUSION: The hunger pain, probably induced by antipsychotics, seemed to reinforce maladaptive coping styles. The relief from hunger pain due to semaglutide was in most cases a liberation. Yet, it is important also to pay attention to the negative effects of reduced hunger. It is relevant to assess patients' eating problems prior to semaglutide treatment. DOI: 10.1080/17482631.2026.2717809 PMCID: PMC13487855 PMID: 42610532 [Indexed for MEDLINE] Conflict of interest statement: The HISTORI RCT: Financial, material, and other support for the study was obtained from private foundations, including the Novo Nordisk Foundation; the Steno Diabetes Centre Sjaelland; the Steno Diabetes Centre Odense, Denmark; Slagelse Research Grants; and Region Zealand Health Research Foundation. The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

What app do you guys use with mounjaro ?

What app do you guys use with mounjaro ?

@Max_hubz KPV

@Max_hubz KPV

Rethinking dog stress behaviours: contextual and physiological insights from the attachment framework.

Monaural and HRT

Monaural and HRT

I avoided SSRIs because the side effects scared me. Always wanted to do things https://t.co/hRRXLj8MSk I inject Selank..

I avoided SSRIs because the side effects scared me. Always wanted to do things https://t.co/hRRXLj8MSk I inject Selank... honestly? I feel better!! Social anxiety had reached the point where even being around longtime friends felt uncomfortable. On Selank, conversations became easier and I stopped analysing myself so much.

Limosilactobacillus reuteri normalizes gut microbiota dysfunction and social deficits of rat offspring associated with prenatal exposure to stress.

Mounjaro isn't helping me lose weight

Mounjaro isn't helping me lose weight

@SSavson https://t.co/rNNujLF2qy https://t.co/GsNR9f3gbg https://t.co/Gey0XkHBRq https://t.co/dv927j0sim This is going

@SSavson https://t.co/rNNujLF2qy https://t.co/GsNR9f3gbg https://t.co/Gey0XkHBRq https://t.co/dv927j0sim This is going to be big. You can see all the investors salivating over it. And just like GLP1 drugs, I already solved this problem. 🤣

Exploring spin-phonon coupling, barocaloric, and polar phonon features in the multiferroic [(CH(3))(2)NH(2)][Mn(N(3))(3)] hybrid perovskite.

Mounjaro after Bariatric Surgery

Mounjaro after Bariatric Surgery

@AtomP2P I don’t think so. The copper is bound to the GHK.

@AtomP2P I don’t think so. The copper is bound to the GHK.

ATR-FTIR spectroscopy coupled with multivariate analysis for monitoring degradation and secondary structure transitions in therapeutic peptide formulations.

Gaining weight on Monjauro

Gaining weight on Monjauro

You’re searching for a GLP-1 but don’t know what the costs are for each of the pharmacies if you have to have a membersh

You’re searching for a GLP-1 but don’t know what the costs are for each of the pharmacies if you have to have a membership, etc. Check this out ⬇️ https://t.co/6w1UmwEjhQ

Associations between human oxytocin receptor gene promoter DNA methylation and brain structural connectome in panic disorder in Korea.

1. J Affect Disord. 2026 Dec 15;415:122425. doi: 10.1016/j.jad.2026.122425. Epub 2026 Aug 26. Associations between human oxytocin receptor gene promoter DNA methylation and brain structural connectome in panic disorder in Korea. Kim HJ(1), Pae C(2), Bang M(1), Kim IB(3), Lee SH(4). Author information: (1)Department of Psychiatry, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea. (2)Brain Imaging Center, Seoul National University, Seoul, Republic of Korea. (3)Department of Psychiatry, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Republic of Korea. Electronic address: ilbin49@chamc.co.kr. (4)Department of Psychiatry, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea. Electronic address: drshlee@cha.ac.kr. AIMS: Epigenetic regulation of the oxytocin receptor gene (OXTR), particularly DNA methylation (DNAm), has been linked to insecure attachment, anxiety-related phenotypes, and suicidality. However, its role in panic disorder (PD) and brain network dysfunction remains unclear. This study examined whether peripheral OXTR DNAm and OXTR DNAm-associated structural connectivity are related to clinical symptoms of PD. METHODS: We investigated OXTR DNAm and its structural connectivity in 563 patients with PD and 210 healthy controls (HCs). Peripheral blood OXTR promoter (-934) DNAm was quantified by pyrosequencing. In a neuroimaging subset, diffusion MRI tractography reconstructed the structural connectome. Network-based statistics tested the diagnosis-by-OXTR DNAm and diagnosis-by-clinical symptomatology effects using separation-related life events (SLEs), Anxiety Sensitivity Index-Revised (ASI-R), and the Scale for Suicidal Ideation (SSI). A preliminary bagging ensemble regression model was used to evaluate treatment response prediction. RESULTS: Patients with PD exhibited significantly lower OXTR DNAm levels than HCs, adjusting for age, sex, education, smoking status, and body mass index. Within PD, reduced OXTR DNAm was significantly negatively correlated with elevated SLEs, ASI-R, and SSI scores. Diagnosis-by-OXTR DNAm interactions revealed reduced connectivity across the hippocampus, amygdala, orbitofrontal, and precentral regions converging on the extended fear network. Importantly, OXTR DNAm-associated connectivity in the orbitofrontal and lateral occipital cortices showed a cross-validated association with the 8-week treatment outcomes. CONCLUSION: Lower peripheral OXTR DNAm was associated with higher PD-related symptomatology and altered extended fear network connectivity. These findings suggest that peripheral OXTR DNAm may index aspects of clinical and neural heterogeneity in PD. Copyright © 2026 Elsevier B.V. All rights reserved. DOI: 10.1016/j.jad.2026.122425 PMID: 42648552 [Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

HW: 270; SW: 220; GW: 170-175; CW: 159-155; BD: 2.5; CD: 5.0

HW: 270; SW: 220; GW: 170-175; CW: 159-155; BD: 2.5; CD: 5.0

Living Leaner Longer Stronger is my blueprint for optimal health and longevity... Built from 25+ years of research, exp

Living Leaner Longer Stronger is my blueprint for optimal health and longevity... Built from 25+ years of research, experimentation, and real-world application. Get your copy on Amazon or read 2 chapters! https://t.co/XhdmGdW0gC https://t.co/cC3Im7vk03

Discovery of a novel and potent KRAS(G12V)-targeting peptide with antiproliferative activity against colorectal cancer cells.

1. J Enzyme Inhib Med Chem. 2026 Dec;41(1):2684700. doi: 10.1080/14756366.2026.2684700. Epub 2026 Jun 11. Discovery of a novel and potent KRAS(G12V)-targeting peptide with antiproliferative activity against colorectal cancer cells. Zhang H(1), Yang S(2), Wang Y(2), Niu MM(2), She J(3). Author information: (1)Department of Hepatobiliary Surgery, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China. (2)Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, Jiangsu, China. (3)Department of Gastrointestinal Surgery, Jintan Affiliated Hospital of Jiangsu University, Changzhou, Jiangsu, China. Despite the clinical relevance of KRASG12V in colorectal cancer, KRASG12V-specific inhibitors remain limited. Through structure-based virtual screening of a 59,319-member peptide library, we identified four KRASG12V-targeting peptides, among which Peptide-1 showed the most favourable docking profile. MST assays confirmed Peptide-1 had the highest affinity among Peptides 1-4, with stronger binding to KRASG12V than to other KRAS mutants. Structural analysis, molecular dynamics simulations, and free-energy calculations indicated that Peptide-1 formed a stable and energetically favourable complex with KRASG12V through extensive hydrogen bonding and hydrophobic interactions. Peptide-1 showed favourable human serum stability and cellular NanoBRET-supported engagement with KRASG12V. Functionally, Peptide-1 displayed potent antiproliferative activity in colorectal cancer cell lines, weaker effects on normal cells and reduced efficacy after KRASG12V knockdown. In SW480 cells, Peptide-1 was associated with reduced ERK1/2 phosphorylation, p21 upregulation, and G0/G1 accumulation. Overall, these findings support further investigation of Peptide-1 as a KRASG12V-targeting peptide for colorectal cancer drug discovery. DOI: 10.1080/14756366.2026.2684700 PMCID: PMC13262105 PMID: 42274165 [Indexed for MEDLINE] Conflict of interest statement: No potential conflict of interest was reported by the authors.

I took a selfie every month on this journey

I took a selfie every month on this journey

I love being tan year-round on Melanotan II. What bothers me is how quickly I get used to the colour and start wanting

I love being tan year-round on Melanotan II. What bothers me is how quickly I get used to the colour and start wanting to be darker again.

Comparison of lifestyle, surgery, and semaglutide for weight management in endometrial cancer: a prospective observational study.

3 Months Completed 28 Lbs Lost(315-287)

3 Months Completed 28 Lbs Lost(315-287)

circadion = epitalon btw https://t.co/IMer5CJIbQ

circadion = epitalon btw https://t.co/IMer5CJIbQ

Recombinant human collagen XVII protects epidermal stem cells from blue light-induced photoaging by downregulating the Notch pathway.

1. Ann Med. 2026 Dec;58(1):2694876. doi: 10.1080/07853890.2026.2694876. Epub 2026 Jul 16. Recombinant human collagen XVII protects epidermal stem cells from blue light-induced photoaging by downregulating the Notch pathway. Wang X(1)(2)(3), Li Q(4), Yang X(1), Bai Y(1), Sui S(1), Ge G(1), Li H(1), Yang R(1). Author information: (1)Department of Dermatology, Seventh Medical Center of Chinese PLA General Hospital, Beijing, China. (2)Department of Dermatology, Medical School of Chinese PLA, Beijing, China. (3)Department of Dermatology, Southern Medical District of Chinese PLA General Hospital, Beijing, China. (4)Medical Health Care Department, Air Force Medical Center PLA, Beijing, China. BACKGROUND: Epidermal stem cell (ESC) degeneration is closely associated with skin aging and functional deterioration. Type XVII collagen (COL17A1) critically regulates ESC polarity and epidermal homeostasis. This study investigated the protective effects of recombinant human COLXVII (rhCol17) against blue light-induced photoaging, particularly on ESC. METHODS: Blue light-induced photoaging models were established using in vitro ESCs and in vivo Sprague-Dawley rats. Transcriptomic profiling was conducted to systematically elucidate the underlying mechanisms. RESULTS: In photoaging ESCs, rhCol17 enhanced ESC viability and migratory capacity, decreased senescence cells, while suppressing ROS production and the secretion of pro-inflammatory factors interleukin (IL)-6, IL-1β and tumor necrosis factor-α. Furthermore, rhCol17 upregulated stem cell markers COL17A1, ITGB1, ITGA6 and P63. In photoaging rat models, rhCol17 alleviated skin dryness, reduced epidermal thickness, delayed aging, and increased the levels of COL17A1 and ITGB1. Importantly, rhCol17 treatment does not affect organ histology or biochemical parameters in rats. Mechanistically, rhCol17 could inhibit the levels of Notch1 and HES1, and senescence markers P16, P21, and P53 in photoaging ESCs and rat skin. Additionally, the ADAM10 inhibitor GI254023X slightly reduced or did not significantly alter the proportion of senescent cells or the expression levels of P16, P21, and P53 in rhCol17-treated BL-induced ESCs, whereas the Notch activator VPA significantly reversed these protective effects of rhCol17. CONCLUSION: This study demonstrates that rhCol17 counteracts blue light-induced ESC dysfunction and epidermal photoaging, suggesting therapeutic potential for photoaging intervention. DOI: 10.1080/07853890.2026.2694876 PMID: 42464532 [Indexed for MEDLINE]

DMV and mounjaro

DMV and mounjaro

bryan once did 5 days of epitalon and never mentioned it again. i wonder why. https://t.co/8VICsGo5RN

bryan once did 5 days of epitalon and never mentioned it again. i wonder why. https://t.co/8VICsGo5RN