Growth hormone

MK-677 (Ibutamoren)

An orally active, long-acting ghrelin-receptor agonist (growth hormone secretagogue) that raises GH and IGF-1 by stimulating the pituitary. Convenient as a once-daily oral, but its sustained, continuous activation is more desensitization- and side-effect-prone (water retention, appetite, insulin sensitivity) than a selective pulsatile injectable like ipamorelin.

Awaiting medical review · community notes open

Common doses

IndicationRouteDoseDurationEvidence
GH/IGF-1 elevation (recovery, sleep, body composition)Oral10–25 mg once dailyTime-limited blocks with breaks; commonly dosed at nightTier 3

Ask about MK-677 (Ibutamoren)

Get an answer from our reviewed articles and community reports, with links to the sources. Not medical advice.

Limitations · Who should NOT use this

Reliably raises IGF-1 and increases fat-free mass on the scale, but much of the early gain is water and strength effects are inconsistent — it is not a steroid-like anabolic. Sustained activation is more desensitization- and side-effect-prone than pulsatile injectables: water retention, increased appetite, and effects on insulin sensitivity and fasting glucose are common considerations. Caution with diabetes, metabolic syndrome, or cancer history. IGF-1 monitoring is advisable. Long-term safety in healthy adults is not established.

Regulatory notes

Not FDA-approved for any indication; investigated but never approved. Available through research-chemical and some gray-market channels. Prohibited in sport — growth hormone secretagogues including ibutamoren are on the WADA prohibited list (S2). Carries metabolic considerations (blood glucose, insulin sensitivity) that warrant medical oversight.

Sources

  1. Murphy MG, et al. MK-677, an orally active growth hormone secretagogue. J Clin Endocrinol Metab 1998;83(2):320-325.
  2. Nass R, et al. Effects of an oral ghrelin mimetic (MK-677) on body composition in healthy older adults. Ann Intern Med 2008;149(9):601-611.
  3. Sigalos JT, Pastuszak AW. The safety and efficacy of growth hormone secretagogues. Sex Med Rev 2018;6(1):45-53.

What Reddit users report — MK-677 (Ibutamoren)

Best-rated real posts mentioning MK-677 (Ibutamoren), summarized with a short quote in the poster’s own words. Of these: 1 worked. Anecdotal community signal — not evidence, not medical advice, and not endorsement.

  • ✓ Workedr/Peptides

    18-year-old considering MK-677, CJC-1295, and ipamorelin for height and muscle gains; seeking advice on protocol selection.

    “I have been considering to take these for height, gained some height lately and i want to make the most out of it before its too late”
    — u/BookkeeperCreepy3526 · read on Reddit ↗

Posts are pulled from public Reddit threads and summarized for context. Individual experiences vary widely and don’t predict your own results. Always consult a qualified clinician.

Community signal — MK-677 (Ibutamoren)

Recent posts and videos mentioning MK-677 (Ibutamoren) from the cron-ingested Reddit + X pipelines and the curated /experts directory. Not endorsement — directional context only.

Community experiences

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Community Notes

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