← All peptidesDelivery format
Sublingual peptides
Peptides absorbed via the oral mucosa, no injection required
Sublingual delivery places peptides under the tongue, where the mucosa absorbs them directly into the bloodstream — bypassing first-pass liver metabolism that destroys oral peptides. Bioavailability sits between oral (~1-3%) and injection (~80-100%) at roughly 10-30% depending on the peptide. Particularly relevant for AOD-9604, oxytocin, and emerging KPV formulations.
3 peptides we cover in this format
Ranked by 30-day query volume
AOD-9604
+8%Fragment of growth hormone (residues 176-191) originally developed for lipolysis. Failed Phase 2b trials for weight loss (Metabolic Pharmaceuticals, 2007). Currently used compounded as an adjunct compound; clinical evidence base is thin and the GH axis indications never reached registration.
Metabolic45K/moResearch onlyOxytocin
+16%Nonapeptide. FDA-approved IV for labor induction; off-label intranasal use for social bonding, sexual response, and autism research. Heinrichs trust-game studies are foundational. Context-dependent: chronic stress, attachment style, and partner dynamics modulate response substantially.
Sexual health35K/moFDA approvedKPV
+18%C-terminal α-MSH tripeptide (Lys-Pro-Val) with documented mast-cell-stabilizing and NF-κB-inhibiting activity. Phase 2 evidence in ulcerative colitis; off-label use in MCAS, IBS, and inflammatory skin protocols. Oral bioavailable via the PepT1 transporter.
InflammationImmune & Gut pillar6.7K/moResearch only
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