Semaglutide vs Tirzepatide

One month update

A little background. 39F. Mom of 4. After 1st baby I lost all the weight doing CrossFit. 2nd baby took me 3 years to lose the weight doing Beach Body workouts and keto. Thought I was done having kids. Surprise baby #3. Gained 90lbs. Lost about 40 lbs when surprise #4. Gained another 90lbs. 3.5 years later and I'm sitting at 80lbs yet of baby weight. Last summer I decided to make a change and started running. Did the couch to 5k program. Then decided to sign up for a 10k. Trained for and ran that. Then my sister in law convinced me to sign up for a 1/2 marathon with her. Trained for and ran that. As accomplished and proud of myself as I am, I still can't look at and appreciate any of my race/post race pictures. In 6 months of running and training I bounced around the same +/- 5lbs and my clothes never got any looser. It was kinda depressing to put in so much work and not see the results I was hoping for. Then after my race I stopped running as long/as frequently and started to see the scale creep back up. Decided to look into GLP-1. Put myself first and used some of our tax return to purchase semaglutide. Started 1 month ago. SW: 210 lbs 5'7" 39f. CW: 200.4lbs Down 19.5 inches too! Including 5 in the bust, 4 in the waist, and 3 in the hips. Started at a very low dose 0.1 and am now up to 0.4. Had some headaches and mild nausea in the beginning but nothing too bad. Working out 4-5 days a week, plus I walk an average of 4-6 miles at work 4x/week. Eating around 1600 calories and drink about 7 owalas/day (always been a big water drinker). I'm so happy I made the decision to start on a sema. It finally gave my body that jumpstart it needed and to put in the work AND see the scale go down has been such a great feeling. Looking forward to month 2!   submitted by   /u/ohmymadeline2587 [link]   [comments]

5 days on Foundayo

I’ve been 5 days on foundayo, which is a new semaglutide medication in pill form. This is my first experience with GLP-1 medicines, and wanted to get some pointers from the community to make this a smooth ride. So far I haven’t noticed any strong side effects, but I’ve noticed a few changes: I will easily feel fool after any meal. Having a bowl of Greek yogurt with granola and chia will make me feel like I had a big lunch with seconds. I’m burping a little more than usual. Since I’m feeling full all the time, I don’t even want to eat anything else between meals. Last couple of nights I had a burning sensation in the stomach while lying in bad. It was manageable, but not very comfortable. I had one pulled pork slider with one serving of potato salad for dinner at 6:30 pm, and was lying in bad at 10 pm. I’m on the starter dose, no nausea, and no significant changes to bowl movements. I guess all of this is normal and expected. Any tips on reducing the burning sensation at night?   submitted by   /u/pfassina [link]   [comments]

Unpopular Opinion about Reta starting dose when transitioning from 15 mg Tirzepatide

**Disclaimer: This is not my opinion, I'm still researching and reading to decide how I will proceed. I got the feedback below from search/*ai* when asking for a hypothetical pharmocology opinion on this. I wanted to share here for your opinions and discussion on how your own experiences confirm or deny what it says. I haven't decided yet how I will proceed with the dosing for myself. Hypothetical feedback: Why you wouldn't start at the intro dose: Retatrutide is a triple agonist (GIP/GLP-1/glucagon receptor), while tirzepatide is a dual agonist (GIP/GLP-1). Someone already on 15 mg tirzepatide, the highest dose, has significant receptor adaptation to GIP and GLP-1 signaling. Starting them at the lowest retatrutide dose (0.5 mg) would be a massive step down in receptor activation, likely leading to the LOSS of appetite suppression , loss of blood sugar control, and loss of weight management progress. This mirrors the semaglutide-to-tirzepatide. Clinicians recognize that receptor tolerance/adaptation carries over between drugs sharing the same mechanism, so they bridge patients at a comparable activity level. Starting dose reasoning: Based on the phase 2 trial data for retatrutide, the efficacious doses ranged from 4 mg up to 12 mg. A clinician transitioning someone from max-dose tirzepatide would likely reason as follows: The GIP/GLP-1 component at around 8–12 mg retatrutide is roughly comparable in potency to higher-dose tirzepatide. So a reasonable starting point might be somewhere in the **8 mg range**, with titration up to 12 mg based on tolerability and response. **The glucagon receptor component is the wildcard.*\ * The patient has zero adaptation to glucagon receptor agonism, which is the novel third mechanism in retatrutide. That component can cause nausea and GI effects on its own. This might argue for a slightly more conservative start — perhaps **6–8 mg** — to let the body adjust to the glucagon piece, even though the GIP/GLP-1 tolerance is already established. **Bottom line hypothetically:** A thoughtful clinician would probably land around 8 mg as a starting dose, titrating up over a few weeks to 12 mg, watching GI tolerability closely because of the new glucagon agonism the patient hasn't been exposed to before. This is just the pharmacological reasoning that would likely apply. My thoughts: INTERESTING 😫 That's seems like a very high start to me😫 but I have no opinion about it yet. We will see!   submitted by   /u/Alive_Site_3071 [link]   [comments]

Unpopular Opinion about Reta starting dose when transitioning from 15 mg Tirzepatide

**Disclaimer: This is not my opinion, I'm still researching and reading to decide how I will proceed. I got the feedback below from search/*ai* when asking for a hypothetical pharmocology opinion on this. I wanted to share here for your opinions and discussion on how your own experiences confirm or deny what it says. I haven't decided yet how I will proceed with the dosing for myself. Hypothetical feedback: Why you wouldn't start at the intro dose: Retatrutide is a triple agonist (GIP/GLP-1/glucagon receptor), while tirzepatide is a dual agonist (GIP/GLP-1). Someone already on 15 mg tirzepatide, the highest dose, has significant receptor adaptation to GIP and GLP-1 signaling. Starting them at the lowest retatrutide dose (0.5 mg) would be a massive step down in receptor activation, likely leading to the LOSS of appetite suppression , loss of blood sugar control, and loss of weight management progress. This mirrors the semaglutide-to-tirzepatide. Clinicians recognize that receptor tolerance/adaptation carries over between drugs sharing the same mechanism, so they bridge patients at a comparable activity level. Starting dose reasoning: Based on the phase 2 trial data for retatrutide, the efficacious doses ranged from 4 mg up to 12 mg. A clinician transitioning someone from max-dose tirzepatide would likely reason as follows: The GIP/GLP-1 component at around 8–12 mg retatrutide is roughly comparable in potency to higher-dose tirzepatide. So a reasonable starting point might be somewhere in the **8 mg range**, with titration up to 12 mg based on tolerability and response. **The glucagon receptor component is the wildcard.*\ * The patient has zero adaptation to glucagon receptor agonism, which is the novel third mechanism in retatrutide. That component can cause nausea and GI effects on its own. This might argue for a slightly more conservative start — perhaps **6–8 mg** — to let the body adjust to the glucagon piece, even though the GIP/GLP-1 tolerance is already established. **Bottom line hypothetically:** A thoughtful clinician would probably land around 8 mg as a starting dose, titrating up over a few weeks to 12 mg, watching GI tolerability closely because of the new glucagon agonism the patient hasn't been exposed to before. This is just the pharmacological reasoning that would likely apply. My thoughts: INTERESTING 😫 That's seems like a very high start to me😫 but I have no opinion about it yet. We will see!   submitted by   /u/Alive_Site_3071 [link]   [comments]

should I try tirzepatide instead?

I've been taking reta for 5 months now, on and off. For the first few months it was consistent weekly, then I've taken breaks when the symptoms got too bad. I've comprehensively experimented between 2-5mg doses after having gotten my body used to it at the start. Consistently, I experience increased food noise than before reta, mainly for sugary foods, but also just never feeling full for long. I experimented taking 5mg and that had me unable to eat anything, but then my body adjusted and the food noise immediately came back. The issue with this is that I thought I was supposed to save money on food on a GLP 1, but am now spending even more lol. The most disruptive thing about it is my bad sleep- I wake up more times in the night than usual and always awaken between 5-6am and can't fall back asleep, regardless of how exhausted I am. Another two side effects I have are constant diarrhea and also alcohol doesn't work AT ALL. However, on it, and even when I haven't taken it for weeks, I am able to maintain a low weight I couldn't even achieve when I was doing OMAD and carnivore or keto and looked 'snatched'. That's fucking awesome lol... That's why I will never go above 4mg now, cos the nausea and not being able to eat (not to mention the expense of buying so many vials) seems to have no purposes if I can eat all the cake in the world and still be a size 2. Anyone with experience with both tirz and reta and has had similar symptoms on reta able to give me any pointers? Thanksss   submitted by   /u/slovakembassy [link]   [comments]

VLS tirzepatide 20 mg

Has anyone got any experience using this pen? I purchased through a friend who had been using. I want to know if anyone else has any experience with this pen? I’ve verified it on the website.   submitted by   /u/a901501 [link]   [comments]