Which peptides do people use for the brain and sleep?

Peptides people use for focus, mood, anxiety and sleep. Cognitive guide →

Semax

Not FDA-approved

Cognitive · studied for Focus / neuroprotection

Research says

C research grade · Tier 4 (In vitro / mechanistic)

Russian clinical use; Western replication thin.

Graded Jun 7, 2026.

Posters say

10 of 19 first-hand posters who gave a verdict on Semax for sleep, focus, mood or longevity said it worked (53%).

3 said results were mixed and 6 said it did not work.

Self-reported on Reddit and X, posts from Jun 9, 2026 – Oct 7, 2026. Unverified — not a success rate. How we count

Stopping: 7 of 34 first-hand posts about Semax mention stopping it.
Time on it: a median of 3 weeks, in the 8 posts that said how long.

Read the guide →See the posts →Play a year on it →

Selank

Not FDA-approved

Cognitive · studied for Anxiety

Research says

C research grade · Tier 4 (In vitro / mechanistic)

Russian anxiolytic data; limited Western evidence.

Graded Jun 7, 2026.

Posters say

11 of 17 first-hand posters who gave a verdict on Selank for sleep, focus, mood or longevity said it worked (65%).

4 said results were mixed and 2 said it did not work.

Self-reported on Reddit and X, posts from Jun 9, 2026 – Oct 8, 2026. Unverified — not a success rate. How we count

Stopping: 5 of 25 first-hand posts about Selank mention stopping it.
Time on it: a median of 3 weeks, in the 5 posts that said how long.

Read the guide →See the posts →Play a year on it →

Cerebrolysin

Not FDA-approved

Cognitive · studied for Neurorecovery (stroke/dementia/TBI)

Research says

A research grade · Tier 2 (Human observational)

Multiple RCTs and approval abroad; modest effect sizes.

Graded Jun 7, 2026.

Posters say

Fewer than 10 first-hand posters gave a verdict on Cerebrolysin for sleep, focus, mood or longevity, so we show no result. 15 first-hand posts mention using it.

Read the guide →See the posts →Play a year on it →

DSIP

Not FDA-approved

Sleep

Research says

DSIP has no research grade yet.

Posters say

Fewer than 10 first-hand posters gave a verdict on DSIP for sleep, focus, mood or longevity, so we show no result. 18 first-hand posts mention using it.

Side effects mentioned: insomnia in 5 of 18 first-hand posts about DSIP; vivid dreams in 5 of 18 first-hand posts about DSIP. These count mentions, not how often it happens.

Read the guide →See the posts →Play a year on it →

Epitalon

Not FDA-approved

Longevity

Research says

Epitalon has no research grade yet.

Posters say

Fewer than 10 first-hand posters gave a verdict on Epitalon for sleep, focus, mood or longevity, so we show no result. 21 first-hand posts mention using it.

Read the guide →See the posts →Play a year on it →

Which peptides act on growth hormone?

Growth-hormone peptides act on the pituitary gland at the base of the brain. Growth Hormone guide →

CJC-1295 / Ipamorelin

Not FDA-approvedBanned in sport (WADA)

Growth hormone · studied for Growth-hormone axis

Research says

C research grade · Tier 4 (In vitro / mechanistic)

Real pharmacology but limited outcome data, unapproved.

Graded Jun 7, 2026.

Posters say

Fewer than 10 first-hand posters gave a verdict on CJC-1295 / Ipamorelin for fat loss, so we show no result. 33 first-hand posts mention using it.

Stopping: 9 of 33 first-hand posts about CJC-1295 / Ipamorelin mention stopping it.
Time on it: a median of 6 weeks, in the 14 posts that said how long.

Read the guide →See the posts →Play a year on it →

Tesamorelin

FDA-approvedBanned in sport (WADA)

Growth hormone · studied for HIV-associated visceral fat

Research says

A research grade · Tier 2 (Human observational)

FDA-approved (Egrifta) with real trial evidence for that use.

Graded Jun 7, 2026.

Posters say

9 of 12 first-hand posters who gave a verdict on Tesamorelin for fat loss said it worked (75%).

3 said results were mixed and 0 said it did not work.

Self-reported on Reddit and X, posts from Jun 7, 2026 – Oct 9, 2026. Unverified — not a success rate. How we count

Stopping: 14 of 42 first-hand posts about Tesamorelin mention stopping it.
Time on it: a median of 5.5 weeks, in the 16 posts that said how long.

Read the guide →See the posts →Play a year on it →

Which peptides are used for the skin?

Peptides for skin, collagen and the skin barrier. Skin & Anti-Aging guide →

GHK-Cu

CosmeticBanned in sport (WADA)

Skin / anti-aging · studied for Topical skin (collagen/barrier)

Research says

B research grade · Tier 3 (Animal)

Best evidence is topical; systemic claims weaker.

Graded Jun 7, 2026.

Posters say

Fewer than 10 first-hand posters gave a verdict on GHK-Cu for healing an injury or the gut, so we show no result. 71 first-hand posts mention using it.

Side effects mentioned: injection-site reaction in 10 of 71 first-hand posts about GHK-Cu. These count mentions, not how often it happens.
Stopping: 16 of 71 first-hand posts about GHK-Cu mention stopping it.
Time on it: a median of 8 weeks, in the 22 posts that said how long.

Read the guide →See the posts →Play a year on it →

Which peptides act on the gut and body weight?

GLP-1 drugs act on appetite and the gut. Some repair peptides are studied for the gut lining. Weight Loss guide →

Tirzepatide

FDA-approved

Metabolic · studied for Obesity / type 2 diabetes

Research says

S research grade · Tier 1 (Human RCT)

GIP/GLP-1 dual agonist; ~21% weight loss in SURMOUNT-1, approved.

Graded Jun 7, 2026.

Posters say

202 of 320 first-hand posters who gave a verdict on Tirzepatide for fat loss said it worked (63%).

100 said results were mixed and 18 said it did not work.

Self-reported on Reddit and X, posts from Jun 8, 2026 – Oct 12, 2026. Unverified — not a success rate. How we count

Side effects mentioned: nausea in 54 of 514 first-hand posts about Tirzepatide; diarrhoea in 35 of 514 first-hand posts about Tirzepatide; fatigue in 31 of 514 first-hand posts about Tirzepatide. These count mentions, not how often it happens.
Stopping: 69 of 514 first-hand posts about Tirzepatide mention stopping it.
Time on it: a median of 10 weeks, in the 289 posts that said how long.

Read the guide →See the posts →Play a year on it →

Semaglutide

FDA-approved

Metabolic · studied for Obesity / type 2 diabetes

Research says

S research grade · Tier 1 (Human RCT)

GLP-1 agonist; large STEP + cardiovascular trials, approved.

Graded Jun 7, 2026.

Posters say

42 of 96 first-hand posters who gave a verdict on Semaglutide for fat loss said it worked (44%).

33 said results were mixed and 21 said it did not work.

Self-reported on Reddit and X, posts from Jun 8, 2026 – Oct 10, 2026. Unverified — not a success rate. How we count

Side effects mentioned: nausea in 27 of 151 first-hand posts about Semaglutide; fatigue in 14 of 151 first-hand posts about Semaglutide; vomiting in 10 of 151 first-hand posts about Semaglutide. These count mentions, not how often it happens.
Stopping: 65 of 151 first-hand posts about Semaglutide mention stopping it.
Time on it: a median of 9.5 weeks, in the 68 posts that said how long.

Read the guide →See the posts →Play a year on it →

Retatrutide

Not FDA-approved

Metabolic · studied for Obesity

Research says

B research grade · Tier 3 (Animal)

Biggest phase-2 weight loss yet (~24%); investigational, phase-3 ongoing.

Graded Jun 7, 2026.

Posters say

34 of 51 first-hand posters who gave a verdict on Retatrutide for fat loss said it worked (67%).

14 said results were mixed and 3 said it did not work.

Self-reported on Reddit and X, posts from Jun 7, 2026 – Oct 11, 2026. Unverified — not a success rate. How we count

Side effects mentioned: fatigue in 7 of 90 first-hand posts about Retatrutide. These count mentions, not how often it happens.
Stopping: 15 of 90 first-hand posts about Retatrutide mention stopping it.
Time on it: a median of 7 weeks, in the 45 posts that said how long.

Read the guide →See the posts →Play a year on it →

BPC-157

Not FDA-approvedBanned in sport (WADA)

Recovery · studied for Gut / tendon repair

Research says

B research grade · Tier 3 (Animal)

Extensive replicated animal data; human trials thin.

Graded Jun 7, 2026.

Posters say

20 of 26 first-hand posters who gave a verdict on BPC-157 for healing an injury or the gut said it worked (77%).

3 said results were mixed and 3 said it did not work.

Self-reported on Reddit and X, posts from Jun 9, 2026 – Oct 9, 2026. Unverified — not a success rate. How we count

Side effects mentioned: injection-site reaction in 5 of 46 first-hand posts about BPC-157. These count mentions, not how often it happens.
Stopping: 6 of 46 first-hand posts about BPC-157 mention stopping it.
Time on it: a median of 8 weeks, in the 14 posts that said how long.

Read the guide →See the posts →Play a year on it →

KPV

Not FDA-approved

Inflammation · studied for Anti-inflammatory (IBD/MCAS)

Research says

C research grade · Tier 4 (In vitro / mechanistic)

Promising preclinical; little human outcome data.

Graded Jun 7, 2026.

Posters say

Fewer than 10 first-hand posters gave a verdict on KPV for healing an injury or the gut, so we show no result. 44 first-hand posts mention using it.

Stopping: 5 of 44 first-hand posts about KPV mention stopping it.
Time on it: a median of 4 weeks, in the 13 posts that said how long.

Read the guide →See the posts →Play a year on it →

Which peptides are studied for muscle metabolism?

Peptides studied for energy use in muscle cells. Longevity guide →

MOTS-c

Not FDA-approved

Metabolic / longevity

Research says

MOTS-c has no research grade yet.

Posters say

Fewer than 10 first-hand posters gave a verdict on MOTS-c for fat loss, so we show no result. 73 first-hand posts mention using it.

Side effects mentioned: injection-site reaction in 7 of 73 first-hand posts about MOTS-c; fatigue in 6 of 73 first-hand posts about MOTS-c. These count mentions, not how often it happens.
Stopping: 10 of 73 first-hand posts about MOTS-c mention stopping it.
Time on it: a median of 2.5 weeks, in the 13 posts that said how long.

Read the guide →See the posts →Play a year on it →

Which peptides do people use for joints and tendons?

Repair peptides people use after tendon, ligament and joint injuries. Recovery guide →

BPC-157 is also studied here. Its full card, with research grade and poster counts, is under Gut & weight.

TB-500

Not FDA-approvedBanned in sport (WADA)

Recovery · studied for Tissue repair

Research says

C research grade · Tier 4 (In vitro / mechanistic)

Thymosin beta-4 fragment; largely animal data.

Graded Jun 7, 2026.

Posters say

8 of 10 first-hand posters who gave a verdict on TB-500 for healing an injury or the gut said it worked (80%).

0 said results were mixed and 2 said it did not work.

Self-reported on Reddit and X, posts from Jul 2, 2026 – Sep 28, 2026. Unverified — not a success rate. How we count

Read the guide →See the posts →Play a year on it →

Which peptides do people use for the brain and sleep?

Semax

Research says

Posters say

Selank

Research says

Posters say

Cerebrolysin

Research says

Posters say

DSIP

Research says

Posters say

Epitalon

Research says

Posters say

Which peptides act on growth hormone?

CJC-1295 / Ipamorelin

Research says

Posters say

Tesamorelin

Research says

Posters say

Which peptides are used for the skin?

GHK-Cu

Research says

Posters say

Which peptides act on the gut and body weight?

Tirzepatide

Research says

Posters say

Semaglutide

Research says

Posters say

Retatrutide

Research says

Posters say

BPC-157

Research says

Posters say

KPV

Research says

Posters say

Which peptides are studied for muscle metabolism?

MOTS-c

Research says

Posters say

Which peptides do people use for joints and tendons?

TB-500

Research says

Posters say

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